The clinical features are such that it is often mistaken for infectious. Although kikuchifujimoto disease has been reported widely, we believe this is the first familial report in the literature of a case of kikuchifujimoto disease occurring in a parent and child. The aetiology is poorly understood, but it appears to be an autoimmune disorder with a possible infectious trigger. Little is known about the causative agent of kikuchifujimoto disease. Kikuchis disease histiocytic necrotizing lymphadenitis. Less frequent symptoms include weight loss, nausea, vomiting, sore throat. Isolated cases are reported in north america, europe, asia and at least two cases new zealand. Kikuchi disease, also called kikuchifujimoto disease or kikuchi histiocytic necrotizing.
It generally affects young subjects under 40 years of age and is characterized by regional lymphadenopathy. The lymph node changes in kawasaki disease mucocutaneous lymph node disease, cat scratch disease and atypical mycobacterial infection are quite different, being characterised by intravascular fibrin thrombi and neutrophils, stellate microabscesses with neutrophils and necrotising stellate granulomatous inflammation respectively. May 23, 2006 kikuchifujimoto disease kfd is a benign and selflimited disorder, characterized by regional cervical lymphadenopathy with tenderness, usually accompanied with mild fever and night sweats. The objective of this study is to analyze the clinicopathological features of kfd. Cervical lymphadenopathy secondary to kikuchifujimoto. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is an. Kikuchifujimoto disease kfd, or histiocytic necrotizing lymphadenitis, is a rare benign, selflimiting cervical lymphadenitis of unknown etiology. Since then, we have not found reports in our country and even less related to pediatric ages. Patients most commonly present with posterior cervical lymphadenopathy 60%90% of cases, frequently with concomitant involvement of axillary andor supraclavicular lymph nodes. Analysis of 244 cases article pdf available in clinical rheumatology 261. Kikuchifujimot disease, bagalore, india, diagnostics, lymph nodes, corticosteroid therapy discussion kikuchi first described the disease in 1972 in japan 1.
Kikuchifujimoto disease is rare, clinicians should be aware of this condition as early diagnosis of the disease will lessen concerns of the patients family. Although the disease has been reported from all over the world and more so from asia, it is rare. Kikuchifujimoto disease darcie deaver, phd, pedro horna, md, hernani cualing, md, and lubomir sokol, md, phd background. Two case reports from north east india authors dr sarat das1, dr navanita das2. My 30 year old son has been but there is so little information on it and the drs he has seen its the first time they have heard of it. Kucukardali y, solmazgul e, kunter e, oncul o, yildirim s, kaplan m. Symptomatic treatment was provided and an uneventful full recovery was made. Cervical lymphadenopathy secondary to kikuchifujimoto disease in a child. The diagnosis procedure, including biopsy, concluded a kikuchi disease, a rare. To date only eight cases have been reported from nepal.
Kikuchifujimoto disease is an extremely rare disease known to have a worldwide distribution with higher prevalence among. Original article, case study by ear, nose and throat journal. Kikuchifujimoto disease is a selflimited clinicopathologic entity that is increasingly recognized worldwide. We report a case of a 29yearold black african woman who was admitted with headache, neck. It appears to affect young adults particularly, but can occur at any age. Pathogenesis, diagnosis, and management of kikuchi. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis was first described in japan in 1972 1, 2. Case report of kikuchifujimoto disease from subsaharan. Urine analysis and peripheral blood smear were normal. Kikuchifujimoto disease is so named because kikuchi and fujimoto were the first scientists to describe it in japan in 1972. Recognition of this condition is crucial, especially because it can easily be mistaken for tuberculosis, lymphoma, or even adenocarcinoma. The disease frequently mimics tuberculous lymphadenitis, malign. Since the first description of the disease by the japanese pathologists kikuchi and fujimoto, 20,39 its etiology has remained unknown, although environmental factors, in particular viruses, have been suspected. Kfd was associated with sle 32 cases, noninfectious inflammatory diseases 24 cases, and viral infections 17 cases.
Pathology clinic, clinical report by ear, nose and throat journal. It is more common in oriental countries, with few reports of its occurrence in. Most cases occur sporadically in people with no family history of the condition. Ultrasound features of pediatric kikuchifujimoto disease. The disease was selflimiting in 156 64% and corticosteroid treatment was necessary in 16 16% of the cases. Kikuchi fujimotos disease kfd is a rare, immunemediated, selflimiting disorder with unique histopathological features. Kikuchis disease, first identified in japan during 1972, is extremely rare with fewer than 50 cases reported in the medical literature. Kikuchifujimoto disease kfd is typically a selflimited, benign illness which presents with fever and lymphadenopathy. Kikuchi fujimoto disease kfd, also known as histiocytic necrotizing lymphadenitis is an uncommon, idiopathic, generally selflimited cause of lymphadenitis. A challenging case of kikuchifujimoto disease associated with. Recognition and early diagnosis of this condition is very critical as it can be easily mistaken for tuberculosis, lymphoma or systemic lupus erythematosus. A female patient died of heart failure, in the context of other haematological autoimmune complications including haemolytic anaemia.
Kikuchifujimoto disease was diagnosed after cervical lymph node biopsy. Medline abstract for reference 29 of kikuchi disease. Kikuchifujimoto disease is characterized by cervical lymphadenopathy occurring in young adults. Symptoms are usually nonspecific fever, night sweats, etc.
Kikuchifujimoto disease kfd manifests in most cases as unilateral cervical lymphadenomegaly, with or without accompanying fever. Fatal kikuchifujimoto disease associated with sle and. Two pediatric cases of kikuchifujimoto disease histiocytic necrotizing lymphadenitis are reported due to its rarity. Jul 24, 20 kikuchifujimoto disease kfd is a rare benign disorder predominantly affecting young adults and has a site predilection for cervical lymph nodes. This study analyzed the clinical manifestations and disease course in children with kfd. Histiocytic necrotising lymphadenitis is a benign condition associated with lymphadenopathy a disease of the lymph nodes.
A challenging case of kikuchifujimoto disease associated. Aseptic meningitis in kikuchi fujimoto disease is described in the literature but is rare. Kikuchifujimoto disease forum questions about kikuchifujimoto disease ask a question and get answers from other users. Neurologic involvement is rare, and testitis directly caused by kikuchifujimoto disease has not yet been reported. Health, general lymphadenitis care and treatment diagnosis patient outcomes research risk factors macrophages health aspects systemic lupus erythematosus development and progression. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is an uncommon, idiopathic, generally selflimited cause of lymphadenitis. Case report the kikuchifujimoto disease in nigeria.
Fujimoto and colleagues described kikuchis disease in the same year. Fujimoto and colleagues independently described the disease in the same year 2. Kikuchifujimoto disease is rare in children, however, it is well documented in the literature. Fujimoto disease also known as histiocytic necrotizing. Kikuchifujimoto disease is more common in female gender 2,3. Histologically, the dermatological manifestations of kikuchifujimoto disease have features in common with systemic lupus erythematosus. Two cases are reported in the japanese literature 1 and one from india. Kikuchifujimoto disease kfd is a rare form of painful lymphadenopathy, usually cervical, which is more common in southeast asia and rarely reported from africa. A retrospective study of 24 cases of kfd presenting at a tertiary care hospital in southern india over a 4 year period is presented here. Kikuchifujimoto disease, also known as subacute necrotizing lymphadenitis or subacute necrotizing histiocytosis, is an idiopathic disease characterized usually by cervical lymph node enlargement 80%. Kikuchifujimoto disease radiology reference article. Pdf kikuchifujimoto disease kfd was first described in japan in 1972. Kikuchis disease nord national organization for rare.
An uncommon presentation of kikuchi fujimoto disease. Histological analysis later suggested kikuchifujimoto disease, also known as histiocytic necrotising lymphadenitis. Kikuchifujimoto disease how is kikuchifujimoto disease. It is rare in caucasians, normally occurring in those of asian descent. The authors report three cases of pediatric kfd that presented at the same institution in a 9month time period. This disease is misdiagnosed as malignant lymphoma in up to onethird of cases. During four years of followup, the patient developed no malignant disease or systemic and autoimmune diseases such as systemic lupus erythematosus. This disease was first described in 1972 in japan 1. Kikuchifujimoto disease prior to childhoodsystemic lupus. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is a rare disease that is frequently underdiagnosed due to clinical features that are similar to those of nonhodgkin lymphomas, systemic lupus erythematosus sle, or infectious reactive lymphadenopathy. Recently, a case study reporting two familial cases of kikuchi disease was published in the literature, raising the hypothesis of genetic factors or perhaps a predisposing genetic background. Kikuchifujimoto disease is a very rare cause of benign lymphadenopathy affecting mainly young asiatic females. A case of a 55 year old gentleman is described here.
Kikuchi disease, also called histiocytic necrotizing lymphadenitis or kikuchifujimoto disease, is an uncommon, idiopathic, generally selflimited cause of lymphadenitis. A rare case of kikuchi fujimotos disease with subsequent. The authors report 4 cases of kikuchifujimoto disease diagnosed in the internal medicine department of ibn sina university hospital in rabat between 2009 and 2010. It is mainly a disease of young adults 2030 years, with a slight bias towards females. He presented with fevers, weight loss and tender cervical lymph nodes. Stats kikuchifujimoto disease kikuchifujimoto disease. Jan 01, 2014 kikuchifujimoto disease kfd, also known as histiocytic necrotizing lymphadenitis, was first described independently in 1972 by kikuchi and fujimoto.
Kikuchifujimoto disease is an extremely rare disease known to have a worldwide distribution with higher prevalence. Kikuchifujimoto disease kfd was described in 1972 as lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. Lactate dehydrogenase and alanine aminotransferase concentrations can be raised. Au kucukardali y, solmazgul e, kunter e, oncul o, yildirim s, kaplan m so clin rheumatol. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is a rare and benign cause of lymphadenopathy. Here, we present a case of a 66yearold italian woman who was extensively examined for right unilateral. One analysis of 244 cases of kfd reported an overall mortality rate of 2. Kuculardali y, solmazgul e, kunter e, oncul o, yildirim s, kaplan m. Kikuchifujimoto disease is selflimiting with acute to subacute course, evolving during several weeks. The cause of this disease is not known, although infectious and autoimmune causes have been.
The mass showed fast growth and was mildly painful. Now he has a softball size lymph node in his abdomen that the drs think might be. Kikuchifujimoto disease is an uncommon disorder with worldwide. May 21, 2009 kikuchifujimoto disease is a selflimiting condition, usually resolving within 4 months, but a low recurrence rate of 3% to 4% has been reported. A 19yearold man was brought to our clinic with complaints of fever. Case report, case study by iranian journal of medical sciences. Kikuchifujimoto disease kfd was first described in japan in 1972. It predominantly affects young women and can closely mimic infective and immunological disorders. A white man with kikuchifujimoto disease mimicking lymphoma. The disease mainly affects young women and has a selflimited course. Case report of kikuchifujimoto disease from subsaharan africa. Kikuchifujimoto disease kfd is a benign and selflimited disorder, characterized by regional cervical lymphadenopathy with tenderness, usually accompanied with mild fever and night sweats. Kikuchis disease is a very rare disease mainly seen in japan.
The illness in may 1999 was similar to the present one and so this case represents a case of recurrent kikuchi fujimoto disease, as in 5% of cases. This may precede, coincide with or develop after the presentation of kikuchis disease 5, 6. Kikuchi disease is a benign self limiting condition of unknown etiology, although infectious and autoimmune causes have been suggested 46. Kikuchifujimoto disease orphanet journal of rare diseases. The disease is characterised by a unilateral posterior cervical lymphadenopathy. First described independently by kikuchi 27 and fujimoto 19 in 1972, kikuchifujimoto disease is increasingly recognized in the literature. Kfd can frequently mimic various diseases including infection, malignancy, and autoimmune disease.
A rare presentation with localized iliac lymphadenitis. Health, general allergens analysis health aspects antihistamines antinuclear antibodies antistreptolysin children diseases corticosteroid drugs corticosteroids hiv hiv viruses lymphadenitis care and treatment. We report a 25 yr old female who presented with fever, polyarthritis and cervical lymphadenopathy. Kikuchifujimoto disease kfd is a selflimiting histiocytic necrotizing lymphadenitis of unknown origin. To our knowledge, the present study of 91 cases is the largest clinical study of kfd in western countries. Kucukardali y1, solmazgul e, kunter e, oncul o, yildirim s, kaplan m. Health, general lymphadenitis care and treatment case studies diagnosis research. He had it in his neck in february 2017 it was removed and he got better. Kikuchi disease, also called kikuchi fujimoto disease or kikuchi histiocytic necrotizing lymphadenitis, was originally described in young women and is a rare, benign condition of unknown cause usually characterized by cervical lymphadenopathy and fever.
Cervical lymphadenopathy, fever and raised erythrocyte sedimentation rate are usual presenting features of. Kikuchifujimoto disease kfd is a rare lymphohistiocytic disorder with an unknown etiopathogenesis. T a retrospective study of 24 cases of kfd presenting at a tertiary care hospital in southern india over a 4 year period is presented here. Statistics of kikuchifujimoto disease map check how this condition affects the daily life of people who suffer it.
Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is an idiopathic, selflimiting disorder that typically causes lymphadenitis of cervical lymph nodes, usually is accompanied by mild fever and night sweats. One was diagnosed by open biopsy and the other by ultrasoundguided fineneedle aspiration biopsy. Kikuchi disease, also called kikuchifujimoto disease or kikuchi histiocytic necrotizing lymphadenitis, was originally described in young women and is a rare, benign condition of unknown cause usually characterized by cervical lymphadenopathy and fever. Kikuchifujimoto disease kfd is a rare, benign, selflimiting disorder that generally presents with cervical lymphadenopathy. Kikuchifujimoto disease kfd is also known as histiocytic necrotizing lymphadenitis. Kikuchifujimoto disease kfd is a rare form of painful lymphadenopathy.
In this case report, we present a 33yearold man with cop, followed by concomitant kikuchi fujimoto disease kfd. Successful treatment of severe kikuchis disease with. Kfd was first described in 1972 by kikuchi and fujimoto and others. Kikuchifujimoto disease, also known as kikuchis disease or histiocytic necrotizing lymphadenitis, is a benign, selflimiting cause of lymphadenopathy, variably associated with systemic symptoms. Kikuchifujimoto disease kfd is a rare benign disorder predominantly affecting young adults and has a site predilection for cervical lymph nodes. The disease frequently mimics tuberculous lymphadenitis, malign lymphoma, and many other benign and malignant conditions. To our knowledge, there is no previous study comparing the clinical and laboratory characteristics of patients from different geographical parts of the world.
Kikuchifujimoto disease is a rare benign, condition of necrotising histiocytic lymphadenitis. It can be idiopathic or associated with a known underlying disease. Kikuchifujimoto disease kfd is a rare cause of cervical lymphadenitis which mostly affects asian women but is sometimes observed in the pediatric population. Kfd, frequently found in east asian countries, is rare in the uk. The patient was a 32yearold female diagnosed with kikuchifujimoto disease via neck lymph node biopsy in august 2006 in the city of mashhad, iran. To our knowledge, there is no previous study comparing the. A higher prevalence of this disease is seen among the asian population. We searched literature records beginning from 1991 and analyzed epidemiological, clinical, and laboratory data of 244 patients including cases diagnosed in our institution reported in 181 publications. Dorfman et al 14 reported 108 cases but data were mainly histopathologic. Sle was more frequent in cases from asia than europe 28 and 9%, respectively.
Kikuchifujimoto disease kfd is a rare entity charac terized by. Mar 15, 2006 kikuchifujimoto disease kfd was first described in japan in 1972. They came to clinical attention because of cervical lymphadenopathy and fever. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is a. Kikuchi first described the disease in 1972 in japan. Kikuchifujimoto disease kfd or histiocytic necrotizing lymphadenitis is a rare, benign, autoimmune condition characterized by lymphadenopathy, fever, and neutropenia. Kikuchifujimoto disease kfd is a rare, benign, generally selflimiting disease that has higher prevalence in asian people with a few cases reported in european countries. Kikuchi disease genetic and rare diseases information. Kikuchifujimoto disease kfd is a rare, selflimiting disorder that typically affects the cervical lymph nodes.
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